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Mechanistically, since SGLT2 is not expressed in cardiomyocytes, SGLT2 inhibitors exert their cardioprotective effects indirectly by targeting noncardiomyocytes, such as by inducing diuresis, modulating neurohormonal activation, and improving metabolism, rather than through direct actions on cardiomyocytes

As for the silybin, 180mg of it comes from the Milk Thistle Phospholipid Proprietary Blend, while the remaining 47.52mg is part of the Siliphos

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Research has also found that changes in the content of EVs are part of promoting certain pathological conditions, making them a promising tool for diagnosis and treatment in reproductive medicine (Giacomini et al., 2020