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Efficacy: the biggest uncertainty One of the biggest unanswered questions around oral GLP-1s is not convenience or appeal, but effectiveness

After accounting for a wide range of potentially influential factors including patient age, sex, socioeconomic status, diabetes severity, and a history of mental ill health, use of GLP-1 receptor agonists was not associated with an increased risk of suicidality compared with DPP-4 inhibitors (3.9 v 3.7 per 1000 person years, respectively) or an increased risk of suicidality compared with SGLT-2 inhibitors (4.3 v 4.6 per 1000 person years, respectively)

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