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However, the incidence of gastrointestinal AEs was generally similar regardless of the background medication subgroup

[5] SURMOUNT-4 ran the same experiment with tirzepatide and got the same answer, a 21% average loss largely surrendered within a year of stopping

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The decrease in HbA 1c of 0.88%-points (9.64 mmol/mol) in this study compares to a mean 0.9%-point decrease reported in the IGNITE study, an observational study ( n = 211) evaluating oral semaglutide use in routine clinical practice in participants with T2D in the USA [25], and to a mean 1.3% reduction in the Swedish cohort ( n = 195) of the SURE study, an observational study of subcutaneously administered semaglutide use in routine clinical practice [26]

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