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The absence of published bioavailability studies, coupled with theoretical limitations, suggests that berberine patches are unlikely to deliver therapeutically relevant amounts of the compound into systemic circulation

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Tirzepatide, a GLP-1/GIP receptor agonist, provides greater weight loss and glycemic benefit in clinical trials, though both require careful dose escalation and gastrointestinal side effect monitoring

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[46] After completing the SURPASS-2 trial (NCT03987919), the company announced in April 2022 that tirzepatide had successfully met its clinical endpoints in obese and overweight participants without diabetes