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Any adverse effects from GLP-1 medicationsincluding persistent nausea, vomiting, abdominal pain, or signs of pancreatitisshould prompt immediate contact with a healthcare professional, regardless of how the medication was obtained

The SELECT trial showed that semaglutide reduced major adverse cardiovascular events (heart attack, stroke, cardiovascular death) in adults with obesity and established cardiovascular disease, without requiring a diabetes diagnosis. The FLOW trial showed kidney benefits with semaglutide use in patients with type 2 diabetes and chronic kidney disease. Improvements in hard clinical outcomes like cardiac events, kidney disease, and death are commonly observed with GLP-1 use, and are due to both the direct effects of treating the obesity, and indirect effects of the medications themselves

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The ring like pattern in vulvar melanosis: a new dermoscopic clue for diagnosis

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