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Losses of 24 percent of starting body weight were not outliers, but the average on the highest dose which makes Retatrutide, on balance, even more effective than Semaglutide and Tirzepatide

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The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo

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For many individuals, visible weight loss typically becomes evident within the first 4 to 6 weeks of using Wegovy