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[9] Glutathione primarily resides intracellularly (cytosolic and mitochondrial compartments)
The cardiovascular improvements appeared consistent across subgroups, suggesting broad applicability of benefits rather than effects limited to specific patient populations
Katoulis et al., 2014
However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics
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