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Table S2 Proteins with significantly altered abundance in ALS compared to HC groups in two consecutive visits

Gene expression: GHK-Cu has been documented to up- or downregulate over 4,000 human genes in cell-culture models, affecting pathways related to inflammation, tissue repair, and antioxidant defense (PMID 29986520)

We also affect water quality, which impacts its availability for human use and ecosystem health

However, other analyses and meta-analyses found inconsistent associations, indicating that vagal propagation may account for a subset of PD cases or operate under specific host/microbiome contexts

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