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However, with the growing evidence supporting use of particular agents in people with type 2 diabetes with specific profiles (comorbidities, overweight/obesity) and with the availability of multiple glucose-lowering agents with good efficacy and acceptable side effect profiles, the initiation of insulin can be postponed in many to later stages of the disease

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Results Preadministration of either ghrelin or GLP-1 abolishes feeding effect of GLP-1 or ghrelin To test whether the interaction between ghrelin and GLP-1 impacts on feeding regulation, we first designed feeding experiments in which these two peptides were administered in a 30-min interval

The performance in the drug group did not change for 24 months in total, while the control group deteriorated continuously and significantly

Source: Borkland v