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Applying this to the previously calculated Human Equivalent Dose (HED) of 85 mg: 85 mg x 0.158 = 13.43 mg of elemental copper

It is a feature

Transdermal estradiol, delivered through patches or gels rather than oral tablets, bypasses the liver entirely, avoiding the first-pass hepatic metabolism that oral estrogen undergoes and that is associated with increased clotting factor production and thrombotic risk

Online tools may not account for recent hypoglycemia, missed meals, steroid use, alcohol, kidney changes, or changes in rapid-acting insulin

That's when you've got personnel that are calling these patients, encouraging them