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Unlike exenatide which was based on exendin-4, semaglutide is based on the structure of human GLP-1 with specific modifications to improve its pharmacological properties

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However, despite accumulating evidence, inconsistencies in findings related to macromolecule and nutrient intake highlight the need for clearer mechanistic insights

The FDA notes that compounding facilities may use different salt forms of semaglutide (such as semaglutide acetate or semaglutide sodium), rather than the original base form that was approved by the FDA