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Nature 420 , 333336 (2002)

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These early immunotherapies were non-specific, however within the past decade the utilization of targeted immunotherapies have risen with monoclonal antibodies that block immune checkpoint molecules, such as cytotoxic T-lymphocyte associated protein4 (CTLA-4), programmed cell death protein-1 (PD-1), and programmed death ligand-1 (PD-L1), adoptive T-cell therapies and oncolytic viruses (151, 153155)

Shifting consumer preferences are partly behind the downward trend, with Americans reducing their intake of caloric sweeteners from 150.9 pounds to 127.4 pounds per capita in 2021 compared to 2000

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