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Moreover, these leukocyte-endothelial cell interactions can also directly contribute to increase BBB permeability by releasing reactive oxygen species, cytokines, and other mediators of barrier disruption [60]

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A methyl group is simply a molecule containing one carbon atom and three hydrogen atoms (CH3)

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For example, it has been found that polydatin promotes mitochondrial biogenesis and protects against mitochondrial oxidative stress via the activation of Sirtuin-1-PGC-1 pathway and Sirtuin-1-Nrf2-ARE pathway in kidney diseases (Huang et al., 2015