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In patient CAS-C, mutations in CTNNB1 , which is linked to melanoma metastasis 19,25 , were found exclusively in brain metastases at residues P44 and S45, both of which regulate beta-catenin 26

Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity

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The already powerful appetite suppression from Retatrutide combined with fasting windows can result in severely inadequate nutrition, particularly protein intake

This temporal dimension is relevant because early aversive suppression and later motivational downregulation are unlikely to be mechanistically identical, even when both are expressed clinically as reduced interest in food