In general, the condition is so widespread that around 60 to 70 percent of the global population is deficient in their production of lactase enzymes
But for women with a BMI over 30, weight-related comorbidities (hypertension, type 2 diabetes, sleep apnea), or psychological impacts of significant weight gain, the clinical need may be substantial
There is no difference for the primary outcome, clinical pregnancy rate in one group (RR (95% CI) 1.16 (0.72, 1.89)
Oral delivery allows these compounds to interact directly with the gastrointestinal tract where they are most needed
The proportion of patients achieving the ADA-recommended target of HbA1c below 7% was also substantially higher with Rybelsus: in PIONEER 7, 58% of oral semaglutide patients reached target compared with just 25% on sitagliptin meaning Rybelsus helped approximately 1.7 times more patients achieve A1C control