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On the other hand, low levels of B12 are uncommon in most healthy adults because the human liver stores vitamin B12 over time

PLoS One 6 , e18394 (2011)

Macrovesicular lipidosis is a reaction to a wide variety of injuries and can also be regarded as a physiological adaptation demonstrated as an imbalance between uptake of lipids from blood and secretion of lipoproteins by the hepatocyte (Goodman and Ishak 2006)

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Progesterone withdrawal through ROS-induction stimulates the activity of NF-B/COX2 signaling as well as cytokines (IL1, IL6, IL8, TNF-, etc.) and matrix metalloproteinases (MMPs) activation [23] resulting in an influx of leukocytes into the uterus and leading into the endometrial breakdown and shedding [16]