R.AcharyaN.PunjaD.TomarA.AcharyaA
Represents the next frontier in obesity pharmacotherapy, targeting multiple hormonal pathways
Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation
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Unfortunately, glutathione is often very low in individuals who have eaten the Western/American Diet or been exposed to toxins such as cigarettes, alcohol and drugs