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Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease
It can be found in seeds, leafy green vegetables, nuts, and vegetable oils
Avoiding allergens completely can be challenging
In Pakistan, where these unsafe whitening creams are easily accessible, awareness is the first step toward prevention