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Therefore, NAD+ is considered likely to be safe. However, there are some concerns that NAD+ supplementation may contribute to cancer growth, and these need to be further explored using well-controlled clinical trials

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The role of heat shock proteins in the heart Basal and stress-induced expression of HSPs in cardiomyocytes Cardiomyocytes exhibit intrinsically high expression levels of HSPs, reflecting the hearts continuous exposure to mechanical load, metabolic demand, and oxidative stress

Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein

So there are a lot of things that are not addressed