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We dont fully understand how, but it seems like this type of B12 could modulate the synthesis of melatonin, a hormone involved in regulating your sleep-wake cycle: Eight young males were subjected to a single blind cross-over test to see the effects of vitamin B12 (methylcobalamin) on the phase-response of the circadian melatonin rhythm to a single bright light exposure

Individuals lacking in B12 can be tormented by symptoms like weakness, tiredness, or even difficulty concentrating and remembering

Potential off-target effects: broad changes to methylation could, in theory, affect gene expression in ways not yet characterised

Solution: Begin with a low dose and gradually increase under guidance

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