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Eliminating these reduces the inflammatory burden and gives immune-modulating peptides a better starting point

The criteria for liver injury were vacuolization of hepatocytes and pyknotic hepatocyte nuclei, activation of Kupffer cells, and enlargement of sinusoids

doi: 10.1074/jbc.M109.053520 68 GengJKlionskyDJ

A 2025 study in Aging Cell confirmed these findings in both normal epithelial and fibroblast cell lines, identifying hTERT upregulation as the primary mechanism in normal cells (4)