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September 6, 2022: FDA and HHS/ASPR authorized an extension to the shelf life from 12 months to 18 months for certain lots of the Pfizer antiviral therapy, Paxlovid (nirmatrelvir tablets and ritonavir tablets co-packaged for oral use)

Delivery method matters

Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot

The ER integrates folding quality control with stress-sensing machinery to regulate cellular proteome load, while mitochondria require dedicated surveillance systems to maintain bioenergetic competence

Schaefer L, Babelova A, Kiss E, Hausser H-J, Baliova M, Krzyzankova M, et al