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This is a concern that applies to all significant weight loss interventions, not just tirzepatide, but it becomes more relevant as the magnitude of weight loss increases

While large human trials are limited, preclinical and translational research, plus growing real-world experience, suggest meaningful benefits for the gastrointestinal tract and musculoskeletal system

Curr Opin Crit Care (2001) 7(1):17

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3 Results 3.1 Literature search results The literature screening process followed a standardized protocol