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As a result, real-world titration patterns often differ significantly from those studied in controlled environments

Whilst GLP-1 receptors are indeed present in various brain regions, including areas involved in mood regulation such as the hippocampus and hypothalamus, their activation by semaglutide does not translate to direct serotonin modulation

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Drake CT, Terman GW, Simmons ML, Milner TA, Kunkel DD, Schwartzkroin PA et al (1994)