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Both clinical and preclinical studies consistently identify oxidative stress as a key mediator in the pain-depression cycle (Yang et al., 2020)

We made these alterations before we conducted data extraction and analysis

Individuals with CBS mutations will be slow to make glutathione.33 Flipping this around, individuals who have slow methylation cycle enzymes will have lower homocysteine levels

Further research is warranted to explore the long-term implications of allulose intake and its application in dietary strategies for the prevention and management of metabolic diseases