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In 2023, a record 10,660 liver transplants were performed in the United States alone, with MASH accounting for 27% of these procedures, making it the second leading indication for liver transplantation

Therefore, although very potent in terms of directly tackling brain iron overload, a non-invasive but direct method is necessary for CNS delivery

Using a non-inferiority methodology one arm ( n = 121) received 60 mg prednisone for 14 days with a 5 days taper, while the other arm ( n = 129) received four intratympanic doses of 40 mg methylprednisolone over 14 days

It reduced antibiotic resistance and directly reduces the viability of certain bacteria (101, 113, 115)

While NAD therapy shows promise in several areas, we emphasize that more clinical research is needed to fully understand its benefits, risks, and best practices