clinicians preference when semaglutide is not suitable American Association of Clinical Endocrinology Consensus Statement: Algorithm for the Evaluation and Treatment of Adults with Obesity/Adiposity-Based Chronic Disease – 2025 Update Semaglutide Tablets

Behavior modifications, a balanced diet, regular exercise, or any physical activities are significant for achieving optimal outcomes

This could make it harder to recognize whether the tiredness is from one medication or both

Semaglutide may be unsuitable or require additional caution in patients who: are pregnant, breastfeeding or trying to conceive have a history of pancreatitis have severe gastrointestinal disease have delayed stomach emptying have significant kidney or liver impairment use insulin or medicines that can cause hypoglycaemia have diabetic retinopathy have an active or previous eating disorder have experienced a serious allergic reaction to semaglutide already use another GLP-1 or GIP/GLP-1 medicine are due to undergo surgery, sedation or general anaesthesia These factors are not all automatic exclusions

Tirzepatide elimination follows predictable mathematics

Conversely, obesity is often associated with slightly elevated TSH levels