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The price difference reflects regulatory status, not just markup: compounded versions skip FDA premarket review, pharmaceutical manufacturing overhead, and branded-drug profit margins - but also the safety and quality assurances those processes provide

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In September 2023, the FDA moved BPC-157 into Category 2 of its 503A bulk substances list, restricting its use in compounding pharmacies pending further review

Moreover, the virus-induced gene silencing of SlGR3 turned the tolerant cultivar into a susceptible one