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Some detox diets incorporate laxatives or diuretics which, if used over long periods, can result in severe dehydration and have adverse effects on major organs or potentially lead to health problems like seizures

NCCIH notes that research does not support alpha-lipoic acid for blood-glucose control, and evidence for neuropathy-related outcomes is mixed

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Deficiency of carnitine blocks the mitochondrial oxidation of fatty acids to carbon dioxide in all tissues and to ketones in the liver, and leads to lipid accumulation in the cytosol