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Zhang Y et al (2022) Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth

With pivotal trial readouts on the horizon, the year ahead could determine whether these devices remain hopeful prototypes or become validated tools in the next era of obesity care.

Targets are not commitments

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Unless developers adjust how they think about risk, subtle but serious issues may slip past traditional GLP safety playbooks