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Frontal cortex concentrations increased by 50% from 2016 to 2024, with dementia cases exhibiting higher accumulation than controls (Nihart et al., 2025)

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Molecular modeling indicates that the substitution of a valine to glutamic acid at residue 411 reduces the binding affinity of linolenic acid, a reported exogenous ligand for the NHR-49 ortholog, HNF4, as well as other potential fatty acid binding partners with comparable structure (Supplementary Fig

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