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As illustrated in Figure 3, GLP-1RAs potentially exacerbate the overvaluation of shape and weight and promote strict dietinga primary mechanism that maintains binge-eating episodes (Fairburn et al., 2003)

Variants in GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, and MC4R rs17782313 can reveal predispositions that inform whether monotherapy optimization or a switch to an alternative single agent may be more appropriate than pursuing unsupported combination treatment