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Further investigations are therefore needed to clarify the potency of l-valine (and other amino acids) in stimulating GLP-1 release in humans and to investigate the postprandial effect of l-valine on blood glucose regulation when given as a preload before a carbohydrate-containing meal

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added a double bind, placebo-controlled RCT of 72 patients with a mean follow-up of 92 weeks (54 - 157 weeks) to the latters meta-analysis which yielded similar results