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In response to increased insulin resistance, the pancreas compensates by secreting higher levels of insulin, resulting in hyperinsulinemia

Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomesan analysis of CENTER-TBI data

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Additionally, most included studies did not consistently report or stratify outcomes based on lifestyle factors such as physical activity or dietary interventions, which may act as important confounders influencing metabolic outcomes

(8) Long-term vitamin B12 deficiency can cause permanent nerve damage and neurological symptoms