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Typical effects reported with these wellness therapies are usually mild and temporary, such as brief flushing or warmth, mild nausea if an infusion runs too fast, or minor irritation at an injection site, and a provider adjusts pacing and technique to keep them to a minimum

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[2] [3] Additional important safety considerations include risk of pancreatitis (discontinue if suspected), gallbladder disease, acute kidney injury from dehydration during severe gastrointestinal adverse events, and potential diabetic retinopathy complications in patients with a history of retinopathy

Red flags that should stop the protocol Certain findings should trigger immediate discontinuation of one or both compounds: IGF-1 levels exceeding the age-appropriate upper normal limit on two consecutive tests Fasting glucose rising above 126 mg/dL or HbA1c above 6.5% (indicating new-onset diabetes) Liver enzymes (ALT or AST) exceeding three times the upper limit of normal Persistent severe nausea, vomiting, or abdominal pain suggesting gastroparesis or pancreatitis New or worsening carpal tunnel syndrome symptoms Peripheral edema that does not resolve with fluid management Any sign of an allergic or hypersensitivity reaction These red flags are not exhaustive