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DermaVue recommends Mounjaro as first-line for most patients, with semaglutide reserved for those with specific clinical indications, budget constraints, or thin-fat phenotype without significant insulin resistance

Tirzepatide stands out among GLP-1 receptor agonists due to its dual action on both GIP and GLP-1 receptors, enhancing weight loss and blood sugar control compared to those that target only GLP-1

Zhu T, Wu XL, Zhang W, Xiao M

While you might experience some friction from pants, its typically less noticeable than waistband irritation