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Muscelli, E

It contributes to the production of collagen, a structural protein that strengthens skin, joints, blood vessels, and mucous membranes

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Small fibre polyneuropathy can result not only in neuropathic pain and other sensations such as pins and needles or itching but also, interestingly, in a very wide range of (familiar) autonomic symptoms including (but not restricted to) dry eyes, dry mouth, orthostatic dizziness, constipation, bladder incontinence, sexual dysfunction, trouble sweating etc (Tavee, Zhou, 2009)

Not reasonable and necessary