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Any compound containing a carboxylic acid (-COOH), such as a protein, or biotin or peptide, can be activated with NHS or Sulfo-NHS to form an NHS ester that will spontaneously react to form covalent amide linkages with proteins and other molecules that contain primary amines (-NH2)

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Neurological disorders associated with low glutathione include compromised DNA repair, impaired myelin maturation, neuroinflammation, Alzheimers, Parkinsons, and other neurodegenerative diseases (Iskusnykh 2022)

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