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Any concerns about medication tolerability, unexpected symptoms, or questions about blood pressure management should be discussed with the healthcare team rather than discontinuing therapy independently

Gastrointestinal (GI) side effects : Other common side effects of semaglutide, such as nausea, diarrhea, and abdominal discomfort, can contribute to fatigue

Xu M, Wu HY, Liu H, Gong N, Wang YR, Wang YX (2017) Morroniside, a secoiridoid glycoside from Cornus officinalis, attenuates neuropathic pain by activation of spinal glucagon-like peptide-1 receptors

Transitioning from semaglutide to tirzepatide is becoming increasingly common as patients and providers explore options that may offer broader metabolic support

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