Additionally, a randomized, double-blind, placebo-controlled trial in 162 elderly people (70 years) with mild vitamin B 12 deficiency found that vitamin B 12 supplementation for 24 weeks, alone or in combination with folic acid, did not improve memory performance (117)
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Reduced efficacy is the primary concern
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The serum fetal Zn level does not appear to significantly affect the transplacental transfer from the mother to the fetus when in situ perfused placentas from guinea pigs are utilized ( Zn placenta absorption when mother is Zn deficient Zn deficiency worldwide is common and is encountered more frequently in lower income countries
