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The analysis of various markers of oxidative stress suggests that ascorbate acts as an antioxidant in vivo

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

This effect appears dose-dependent and usually stabilises after several weeks of treatment