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An abnormal change in gene structure/mutation, of the MTHFR gene can cause a disruption of the MTHFR enzymes normal function of breaking down homocysteine

[DOI] [PubMed] [Google Scholar] 138.Yeo Y.H., Rezaie A., Hsieh T.Y., Hu X., Gaddam S., Ma K.S., Gastrointestinal Motility and Metabolic Pharmacoepidemiology Group

The three transmembrane proteins mediate three signaling pathways, which can maintain the stability of ER protein synthesis to a certain extent in the early stage of steatosis, but under the continuous stimulation of lipids and ROS, the three transmembrane proteins mediate the signaling pathways that can activate cellular inflammation and apoptosis, accelerating the progression of hepatic steatosis (66)

doi: 10.1016/j.cmet.2021.01.015 139 LarsenPJTang-ChristensenMHolstJJOrskovC

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