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Affinity purification and mass spectrometry analysis have shown that Erastin interacts with voltage-dependent anion channel 2 (VDAC2) (103), reducing the permeability of VDAC2 to the reduced form of nicotinamide adenine dinucleotide (NADH), altering its ion selectivity, and disrupting mitochondrial respiratory chain oxidative phosphorylation (104)
It works by absorbing water to form a gel that softens stool and increases bulk
In conclusion, hypoxia is an important factor leading to tubular injury in DKD
PMID 9264312
Association between high uric acid and the risk of Parkinsons disease: a meta-analysis
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