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More concerning reactions requiring immediate medical attention include severe persistent abdominal pain potentially indicating pancreatitis, symptoms of allergic reactions including rash, itching, or difficulty breathing, or signs of hypoglycemia such as excessive sweating, confusion, or rapid heartbeat
If it goes the estrogen route, androstenedione is converted (using CYP19A1) first to estrone (E1), which is then converted (using 17-HSD) into estradiol.[ref] Here is a flow chart to give you a better idea of the conversion of cholesterol into estrogen, including the genes that are involved
doi: 10.1016/j.ejphar.2023.175896 49 LiuWJJinHYLeeKAXieSHBaekHSParkTS
Biological & pharmaceutical bulletin
Impact of metformin on immunity and male fertility in rabbits with alloxan-induced diabetes
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