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However, if left untreated, it can progress and cause: Chronic fatigue and overall weakness Dizziness Pale or yellowish skin tone Mental health problems such as depression, mood swings, irritability, and anxiety Loss of appetite, nausea, and diarrhea, leading to weigh loss Paresthesia: numbness, tingling or burning sensation in feet, legs, and hands Vision problems Vitamin B12 is an essential nutrient, meaning everyone should get it either from food or supplements

Oral, intravenous, inhaled, and topical routes each carry distinct side effect risks and bioavailability considerations

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58 Long-term or extreme ERS also leads to endoplasmic reticulum dysfunction and further induces cell apoptosis