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CV risk profile subgroups To assess the effect of baseline CV risk profiles on outcomes, two separate subgroup analyses were performed: (1) for subjects who had experienced a prior MI or stroke compared with those who had not, and (2) for those with established CVD, defined as prior stroke, ischemic heart disease (including MI), peripheral arterial disease, 50% arterial stenosis in any artery, coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft), or heart failure vs those with CV risk factors alone and no manifestations of CVD as defined above

To further assess the varying relationship of metabolites with eGFR we computed boosted trees models predicting eGFR with serum metabolomics as the input variable, with a similar methodology to TMAO

Acetyl-L-Carnitine (ALC) is a modified amino acid that supports cellular energy production by assisting in the transport of fat into the mitochondria

Johnsons team hopes to change by studying ways to predict who might develop severe or chronic side effects

However, patients may experience spotting due to other factors, including weight loss-induced hormonal changes, contraceptive interactions, or underlying gynecological conditions