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Both medications improve cholesterol primarily through weight loss, but tirzepatides additional GIP receptor activity appears to enhance lipid metabolism beyond what GLP-1 stimulation alone achieves

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Expression of glucose-dependent insulinotropic peptide receptor ( GIPR ) was detected in three cardiac populations: ventricular and atrial cardiomyocytes (marked by RYR2 as in Figure 1D), adipocytes (marked by ADIPOQ ), and pericytes (marked by ABCC9 ) (Figure 1G)

64 , e1900245 (2020)