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[DOI] [PubMed] [Google Scholar] 86.Ookhtens M., Kaplowitz N
However, when viral infection, environmental stress, or immunosuppression impairs these defenses, microbes from the oral cavity and URT can aberrantly colonize the LRT, markedly increasing the risk of BRD through pathogenic mechanisms and microbial agents similar to those described in the URT section above
Probiotics repair and fortify these multilayered barriers through multi-target, synergistic mechanisms, and their effects are highly strain-specific ( Prioritizing the chemical and immune barriers, Lactobacillus plantarum HNU082 increases short-chain fatty acid (SCFA) levels, which stimulate goblet cells to secrete MUC2, strengthening the chemical barrier, and reestablishes immune homeostasis by inhibiting NF-B and bidirectionally modulating cytokine production (Wu et al., 2022