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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

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Folia Microbiol 69:713722 Chung CF, Lin SC, Juang TY, Liu YC (2020) Shaking rate during production affects the activity of Escherichia coli surface-displayed Candida antarctica lipase A

It has allowed researchers and clinicians to interpret medical data and predict outcomes more accurately