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Increasing GLP-1 naturally may help to support appetite and metabolic health, but its important to keep expectations realistic as the effects are usually modest compared to medications

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With respect to liver metabolism, studies have shown that Scrophulariae Radix significantly regulates phospholipid metabolites such as phosphatidylcholine and phosphatidylethanolamine, aiding in restoring lipid metabolism balance and preventing common lipid metabolic disorders in hyperthyroid patients (102)

All those differences might explain differential adaptations (tolerance or no tolerance) depending on the agonist and dosing regimen